The University of Hong Kong

Main Content

   Publication(s) - Herbal Medicine

1. Man SC, Li XB, Wang HH, Yuan HN, Wang HN, Zhang RG, Tan QR, Wong HK, McAlonan GM, Wang CY, Zhang ZJ*. (2016) Peony-Glycyrrhiza Decoction for antipsychotic-related hyperprolactinemia in women with schizophrenia: a randomized controlled trial. Journal of Clinical Psychopharmacology, 36: 572–579.
2. Tian DD, Wang W, Wang HN, Sze SCW, Zhang ZJ*. (2016) Pharmacokinetic evaluation of clozapine in concomitant use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, and Fructus Gardeniae in rats. Molecules, 21. pii: E696.
3. Wang W, Tian DD, Zhang ZJ*. (2016) In-vitro effects of concomitant use of herbal preparations on cytochrome P450s involved in clozapine metabolism. Molecules, 21. pii: E597.
4. Leigh AB, Cheung HP, Lin LZ, Ng TB, Lao L, Zhang Y, Zhang ZJ, Tong Y, Sze SC. (2016) Comprehensive and holistic analysis of HT-29 colorectal cancer cells and tumor-bearing nude mouse model: interactions among fractions derived from the Chinese medicine formula Tian Xian liquid in effects on human colorectal carcinoma. Integrative Cancer Therapies, pii: 1534735416651969.
5. Wang D, Zhang Y, Wang C, Jia D, Cai G, Lu J, Wang D, Zhang ZJ*. (2016) 18β-Glycyrrhetinic acid, a novel naturally derived agent, suppresses prolactin hyperactivity and reduces antipsychotic-induced hyperprolactinemia in in vitro and in vivo models. Neurochemical Research, 41: 2233-2242.
6. Wang XD, Qiao MQ, Zhang ZJ, Chen G, Chen JX, Tu Y. The research progress in TCM treatment of major depression. (2016) Journal of Nanjing University of Traditional Chinese Medicine, 32: 93-96.
7. Li S, Tan HY, Wang N, Zhang ZJ, Lao LX, Wong CW, Feng YB. (2015) The role of oxidative stress and antioxidants in liver diseases. International Journal of Molecular Sciences, 16: 26087-26124
8. Wang D, Wang W, Zhou Y, Wang J, Jia D, Wong HK, Zhang ZJ*. (2015) Studies on the regulatory effect of Peony-Glycyrrhiza Decoction on prolactin hyperactivity and underlying mechanism in hyperprolactinemia rat model. Neuroscience Letters, 606; 60-65.
9. Wang S, Tong Y, Ng TB, Lao L, Lam JK, Zhang KY, Zhang ZJ, Sze SC. (2015) Network pharmacological identification of active compounds and potential actions of Erxian decoction in alleviating menopause-related symptoms. Chinese Medicine, 10: 19.
10. Wang W, Tian DD, Zheng B, Wang D, Tan QR, Wang QY, Zhang ZJ*. (2015) Peony-Glycyrrhiza Decoction, an herbal preparation, inhibits clozapine metabolism via cytochrome P450s, but not flavin-containing monooxygenase in in vitro models. Drug Metabolism & Disposition, 43: 1147-1153.
11. Zheng Y, Zhang ZJ*, Han XM, Ding Y, Chen YY, Wang XY, Wei XW, Wang MJ, Cheng Y, Nie ZH, Zhao M, Zheng XX. (2015) A proprietary herbal medicine (5-Ling Granule) for Tourette syndrome: a randomized controlled trial. The Journal of Child Psychology and Psychiatry, 57: 74-83.
12. Wong KL, Lai YM, Li KW, Lee KF, Ng TB, Cheung HP, Zhang YB, Lao L, Wong NSR, Shaw PC, Wong JH, Zhang ZJ, Lam JKW, Ye W, Sze SCW. (2015) A novel, stable, estradiol-stimulating, osteogenic yam protein with potential for the treatment of menopausal syndrome. Scientific Reports, 5:10179.
13. Hsu WWQ, Chan EWY, Zhang ZJ, Bian ZX, Lin ZS, Hsia YF, Wong ICK. (2015) A survey to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong: a survey study to investigate attitudes and perceptions of Chinese medicine professionals in health information technology in Hong Kong. European Journal of Integrative Medicine, 7: 36-46.
14. Hsu WWQ, Zhang ZJ, Bian ZX, Lin ZS, Wong I. (2015) Chinese medicine students' views on electronic prescribing: a survey study in Hong Kong. European Journal of Integrative Medicine. European Journal of Integrative Medicine, 7: 47-54.
15. Wang N, Feng Y, Cheung F, Wang X, Zhang Z, Feng Y. (2015) A Chinese medicine formula Gegen Qinlian Decoction suppresses expansion of human renal carcinoma with inhibition of matrix metalloproteinase-2. Integrative Cancer Therapies, 14: 75-85.
16. Liu LY, Feng B, Chen J, Tan QR, Chen ZX, Chen WS, Wang PR, Zhang ZJ*. (2015) Herbal medicine for hospitalized patients with severe depressive episode: a retrospective controlled study. Journal of Affective Disorders, 170: 71-77.
17. Wong KL, Wong RNS, Zhang L, Liu WK, Ng TB, Shaw PC, Kwok PCL, Lai YM, Zhang ZJ, Zhang YB, Tong Y, Cheung HP, Liu J, Sze SCW. (2014) Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential. Chinese Medicine, 9: 19.
18. Wang D, Wong HK, Feng YB, Zhang ZJ*. (2014) 18beta-Glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway. Journal of Neuro-Oncology, 116: 221-230.
19. Wang D, Lu CY, Teng LS, Guo ZH, Meng QF, Liu Y, Zhong LLD, Wang W, Xie J, Zhang ZJ*. (2014) Therapeutic effects of Chinese herbal medicine against neuroendocrinological diseases especially related to hypothalamus-pituitary-adrenal and hypothalamus-pituitary-gonadal axis. Pakistan Journal of Pharmaceutical Sciences, 27(3 Supp): 741-754.
20. Wang H, Zhang R, Qiao Y, Xue F, Nie H, Zhang Z, Wang Y, Peng Z, Tan Q. (2014) Gastrodin ameliorates depression-like behaviors and up-regulates proliferation of hippocampal-derived neural stem cells in rats: Involvement of its anti-inflammatory action. Behavioural Brain Research, 266: 153-160.
21. Chen HY, Ma CH, Cao KJ, Ho CM, Ziea ETC, Wong VT, Zhang ZJ*. (2014) A systematic review and meta-analysis of herbal medicine on chronic obstructive pulmonary diseases. eCAM 2014, 925069.
22. Chen HY, Ma CH, Cao KJ, Ho CM, Ziea ETC, Wong VT, Zhang ZJ*. (2014) A systematic review and meta-analysis of herbal medicine on chronic obstructive pulmonary diseases. eCAM 2014, 925069.
23. Wang D, Wong HK, Feng YB, Zhang ZJ*. (2013) Liquiritigenin exhibits anti-tumor action in pituitary adenoma cells via Ras/ERKs and ROS-dependent mitochondrial signaling pathways. Journal of Pharmacy and Pharmacology, 66: 408-417.
24. Yang YH, Chen HY, Zhong JH, Zhang ZJ*. (2014) Clinical trials of traditional Chinese medicine for insomnia: current status and future directions. World Journal of Sleep Medicine, 1: 54-58.
25. Wang D, Tan QR, Zhang ZJ*. (2013) Neuroprotective effects of paeoniflorin, but not the isomer albiflorin, are associated with the suppression of intracellular calcium and calcium/calmodulin protein kinase II in PC12 cells. Journal of Molecular Neurosciences, 51: 581-590.
26. Ma CH, Lin WL, Lui SL, Cai XY, Wong VT, Ziea E, Zhang ZJ*. (2013) Chinese herbal medicine for benign prostatic hyperplasia: systematic review and meta-analysis. Asian Journal of Andrology, 15: 471-482.
27. Wang D, Wong, HK, Feng YB, Zhang ZJ*. (2013) Peoniflorin, a natural neuroprotective agent, modulates multiple antiapoptotic and apoptotic pathways in differentiated PC12 cells. Cellular and Molecular Neurobiology, 33: 521–529.
28. Zhong LLD, Tong Y, Tang GWK, Zhang ZJ, Choi WK, Lok CK, Sze SCW, Kun W, Liu Q, Yu BXB. (2013) A randomized double-blinded controlled trial of a Chinese herbal formula (Er-Xian Decoction) for menopausal symptoms in Hong Kong perimenopausal women. Menopause [Epub ahead of print]
29. Yeung WF, Chung KF, Poon MMK, Ho FYY, Zhang SP, Zhang ZJ, Ziea ETC, Wong VT. (2012) Prescription of Chinese herbal medicine and selection of acupoints in pattern-based traditional Chinese medicine treatment for insomnia: a systematic review. Evidence-based Complementary and Alternative Medicine, 2012:902578.
30. Wang N, Zhu M, Tsao SW, Man K, Zhang ZJ, Feng Y. (2012) Up-Regulation of TIMP-1 by Genipin Inhibits MMP-2 Activities and Suppresses the Metastatic Potential of Human Hepatocellular Carcinoma. PLoS One, 7:e46318.
31. Wang D, Wong HK, Zhang L, McAlonan GM, Wang XM, Sze SCW, Feng YB, Zhang ZJ*. (2012) Not only dopamine D2 receptors involved in Peony-Glycyrrhiza Decoction, an herbal preparation against antipsychotic-associated hyperprolactinemia. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 39: 332-338.
32. Chung KF, Yeung WF, Zhang ZJ, Yung KP, Man SC, Lee CP, Lam SK, Leung TW, Leung KY, Ziea ETC, Wong VT. (2012) Randomized placebo-controlled pilot trial of electroacupuncture for postpartum depression. Journal of Affective Disorders, 142: 115-121.
33. Zhang ZJ*, Wang XM, McAlonan GM. (2012) Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture. Evidence-based Complementary and Alternative Medicine, 2012: 429412.
34. Yeung WF, Chung KF, Poon MK, Ho YY, Zhang SP, Zhang ZJ, Ziea TC, Wong VT. (2012) Chinese herbal medicine for insomnia: a systematic review of randomized controlled trials. Sleep Medicine Reviews, 16: 497-507.
35. Sze SC, Cheung HP, Ng TB, Zhang ZJ, Wong KL, Wong HK, Hu YM, Yow CM, Tong Y. (2011) Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause. Chinese Medicine, 6: 40.
36. Sze SC, Cheung HP, Ng TB, Zhang ZJ, Wong KL, Wong HK, Hu YM, Yow CM, Tong Y. (2011) Effects of Erxian decoction, a Chinese medicinal formulation, on serum lipid profile in a rat model of menopause. Chinese Medicine, 6: 40.
37. Qin F, Wu XA, Tang Y, Huang Q, Zhang ZJ, Yuan JH. (2011) Meta-analysis of randomized controlled trials to assess the effectiveness and safety of Free and Easy Wanderer Plus, a polyherbal preparation for depressive disorders. Journal of Psychiatric Research, 45: 1518-1524.
38. Zhang ZJ*, Tan QR, Tong Y, Wang XY, Wang HH, Ho LM, Wong HK, Feng YB, Wang D, Ng R, McAlonan GM, Wang CY, Wong VT. (2011) An epidemiological study of the concomitant use of Chinese medicine and antipsychotics in schizophrenic patients: implication for herb-drug interaction. PLoS One, 6: e17239.
39. Gao M, Chu HY, Jin GZ, Zhang ZJ, Wu J, Zhen XC. (2011) l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT(1A) receptor partial agonistic activity. Synapse.65: 379-387.
40. Lin X, Sze SCW, Tong Y, Zhang ZJ, Feng YB, Chen JP, Ng TB, Lin X, Shaw PC, Zhang KYB. (2010) Protective effect of Dendrobium officinale polysaccharides on experimental Sjogren’s Syndrome. Journal of Complementary and Integrative Medicine, 7: 14.
41. Jiang X, Zhang ZJ, Zhang S, Gamble EH, Jia M, Ursano RJ, Li H. (2011) 5-HT2A receptor antagonism by MDL 11,939 during inescapable stress prevents subsequent exaggeration of acoustic startle response and reduced body weight in rats. Journal of Psychopharmacology, 25: 289-297.
42. Wang HN, Peng Y, Tan QR, Wang HH, Chen YC, Zhang RG, Wang ZZ, Guo L, Liu Y, Zhang ZJ*. (2009) Free and Easy Wanderer Plus (FEWP), a polyherbal preparation, ameliorates PTSD-like behavior and cognitive impairments in stressed rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 33: 1458-1463.
43. Sze SCW, Tong Y, Zhang YB, Zhang ZJ, Lau ASL, Wong HK, Tsang KW, Ng TB. (2009) A novel mechanism: Erxian Decoction, a Chinese medicine formula, for relieving menopausal syndrome. Journal of Ethnopharmacology, 123: 27-33.
44. Zhang ZJ, Tong Y. Zou J, Chen PJ, Yu DH. (2009) Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances endurance performance in healthy volunteers. Chinese Journal of Integrative Medicine, 15: 177-183.
45. Yuan HN, Wang CY, Sze CH, Tong Y, Tan QR, Feng XJ, Liu RM, Zhang JZ, Zhang YB, Zhang ZJ*. (2008) A randomized crossover comparison of herbal medicine and bromocriptine against isperidone-induced hyperprolactinemia in patients with schizophrenia. Journal of Clinical Psychopharmacology, 28: 264-370.
46. Zhang ZJ*, Kang WH, Li Q, Tan QR. (2007) The beneficial effects of the herbal medicine Free and Easy Wanderer Plus (FEWP) for mood disorders: double-blind, placebo-controlled studies. Journal of Psychiatric Research, 41: 828-836.
47. Zhang ZJ*, Tong Y, Wang XY, Yao SM, Jin GX. (2007) Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial. Schizophrenia Research, 92: 273-275.
48. Zhang ZJ*, Kang WH, Tan QR, Li Q, Gao CG, Zhang FG, Wang HH, Ma XC, Chen C, Wang W, Guo L, Zhang YH, Yang XB, Yang GD. (2007) Adjunctive herbal medicine with carbamazepine for bipolar disorders: A double-blind, randomized, placebo-controlled study. Journal of Psychiatric Research, 41: 360-369.
49. Zhang ZJ*. (2004) Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders (review). Life Sciences, 75: 1659-1699.
50.

Zhang ZJ*, Qian YH, Hu HT, Yang J, Yang GD. (2003) The herbal medicine Dipsacus asper Wall extract reduces the cognitive deficits and overexpression of beta-amyloid protein induced by aluminum exposure. Life Science, 73: 2443-2454.
51. Qian YH, Hu HT, Yang J, Zhang ZJ, Wang WX, Yang GD. (1999) Effect of Dipsacus Asper on the expression of amyloid precursor protein in the dorsal hippocampal formation in rat model of Alzheimer’s disease. Chinese Journal of Neuroscience (Chin), 15: 134-138.
52. Zhang ZJ* (1993) Pharmacology of Chinese herbs in the treatment of Alzheimer’s disease (review). J Xi'an Med Univ (Chin), 13:187-189.
53. Zhang ZJ. (1984) The external application of an empirical TCM preparation for the treatment of thromboangitis obliterans. Shanghai Journal of Traditional Chinese Medicine (Chin), (2): 23.